Rats with RMTg lesions by ibotenic acid for 8 days showed a deficit in rebound of non-rapid eye movement (NREM) sleep quality in response to 6-hour sleep deprivation (SD).

<p>(A, B) Time course of NREM sleep in control (A) and RMTg lesioned rats (B). Sleep was deprived from 13:00 to 19:00 hours. (C, D) Total NREM sleep (C) and mean duration of NREM sleep (D) during 19:00–21:00 hours following 6-hour SD. (E, F) Time course of slow-wave activity (SWA) (expressed as percentage of delta power [0.5–4 Hz] in NREM sleep per hour) during 19:00 to 07:00 hours following 6-hour SD in control (E) and RMTg lesioned rats (F). *<i>p</i> < 0.05, **<i>p</i> < 0.01 versus corresponding baseline using 2-way ANOVA followed by paired <i>t</i> tests. Control (<i>n</i> = 6); lesion (<i>n</i> = 4). The horizontal open and filled bars on the <i>x</i>-axes indicate the 12-hour light and the 12-hour dark period, respectively. Underlying data can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002909#pbio.2002909.s001" target="_blank">S1 Data</a>.</p>