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Rapid and efficient thiocyanation of phenols, indoles, and anilines in 1,1,1,3,3,3-hexafluoro-2-propanol under ultrasound irradiation

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Version 2 2017-12-22, 14:29
Version 1 2017-10-23, 15:06
journal contribution
posted on 2017-12-22, 14:29 authored by Zhonghao Wang, Liang Wang, Qun Chen, Ming-yang He

An efficient ultrasound-promoted thiocyanation of phenols, indoles, and anilines in the presence of N-chlorosuccinimide and NH4SCN using 1,1,1,3,3,3-hexafluoro-2-propanol as the solvent has been developed. The major features of the present protocol include the mild reaction conditions, short reaction times, good to excellent yields, and broad substrate scope. Moreover, scale-up synthesis can be achieved and the solvent can be easily recovered and reused.

Funding

This work was supported by the National Natural Science Foundation of China [Grant Number 21302014].

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