ed6b00355_si_011.zip (83.78 MB)
Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment
dataset
posted on 2016-09-30, 17:54 authored by John S. Fossey, Eric V. Anslyn, William
D. G. Brittain, Steven D. Bull, Brette M. Chapin, Cécile S. Le Duff, Tony D. James, Glenn Lees, Stephanie Lim, Jennifer
A. C. Lloyd, Charles V. Manville, Daniel T. Payne, Kimberley A. RoperAn undergraduate chemistry experiment
that draws from primary research
is described. The experiment exploits chiral supramolecular assemblies
for the determination of enantiomeric excess by 1H NMR
spectroscopy. This report describes the delivery of the experiment
to a cohort of students, and as a result of feedback from those involved,
an optimized protocol is presented. Particular care has been taken
to facilitate ready adoption in other institutions by providing comprehensive
teaching support materials as well as technical guidance for supporting
the experiment.
