RNA processing events and gene expression changes following treatment.

A) Diagram depicting the 8 types of RNA splicing changes characterized in this work: alternative first exon, mutually exclusive exon, skipped exon, alternative 5’ splice site, retained intron, alternative 3’ splice site, alternative last exon, and tandem untranslated region. B) Graph showing the estimated proportion of each event type within a given treatment resulting from a logistic model. C) Proportion of significant changes in events over the total number of events that were tested in that treatment. Each bar combines all cell types treated with the compound. Error bars denote the standard error from a binomial test. The dotted line indicates the average proportion of significant events across all treatments.