RNA-mediated molecular epigenetics and virus-driven entropy
Energy-dependent
molecular epigenetics support Einstein's complete molecular mechanical theory
via established links from microRNA flanking sequences to DNA base pair
substitutions and amino acid substitutions in adhesion proteins. The adhesion
proteins include heat shock proteins that link the epigenetic landscape to
biophysically constrained nutrient-dependent RNA-mediated protein folding
chemistry and cell type differentiation via the structure and function of
supercoiled DNA. Einstein's theory fits into the context of Darwin's
"conditions of life" via the de novo creation of nucleic acids; the nutrient-dependent
function of the ribosome; and the de novo creation of olfactory receptor
genes. De novo gene creation is the "holy
grail" of biophysically constrained chemistry and biologically-based cause
and effect. The discoveries reviewed here link the nutrient-dependent
microRNA/messenger RNA balance from metabolic networks to genetic networks and
to healthy longevity or virus-driven pathology in the context of what is known
about all model organisms.
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