Fig 2.TIF (601.32 kB)

RLIPC elevates ST segment prior to induction of cardiac ischemia in rat model of arrhythmia.

figure

posted on 2016-10-21, 17:30 authored by Zhaoyang Hu, Sheng Hu, Shuai Yang, Mou Chen, Ping Zhang, Jin Liu, Geoffrey W. Abbott

A) Left, typical ECGs from CON and RLIPC rats during baseline periods showing elevated ST segment in RLIPC-treated rats. Right, quantification of parameters from ECGs showing elevated ST segment in RLIPC rats post liver I/R stimulus (n = 9–10, each group). *P<0.05, **P<0.01, vs. RLIPC in the presence of liver I/R cycles. B) Variables recorded during the experimental protocol investigating the effect of liver I/R stimulus on hemodynamics prior to coronary artery ligation. LVSP, left ventricular systolic pressure; LVEDP, left ventricular end-diastolic pressure; ±dP/dtmax, maximum rate of increase/decrease in left ventricular pressure. Data are the mean±SEM (n = 6–7 in each group). *P<0.05 compared with values at Baseline 1. Baseline 1 indicates the first baseline value after 10 minutes stabilization; Baseline 2 indicates the second baseline value obtained 5 minutes prior to coronary ligation. Hearts in RLIPC group experienced four cycles of I/R stimulus, indicated as 1, 2, 3, 4.