Quantification of fluorochrome accumulation in a double xenografted mouse by FMT
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posted on 2011-12-31, 18:09 authored by Alexander Wall, Thorsten Persigehl, Peter Hauff, Kai Licha, Michael Schirner, Silke Müller, Angelika von Wallbrunn, Lars Matuszewski, Walter Heindel, Christoph BremerFluorescence-mediated tomography (FMT) was performed 24 hours after injection of SIDAG in order to resolve the three-dimensional fluorochrome distribution and for quantification of fluorochrome concentration in the target tissue: panel a shows a white light image, panel b shows colour-coded FMT data for MDA-MB435, and panel c shows the DU4475 xenograft superimposed on white light images. The average fluorochrome concentration in the MDA-MB xenografts ranged around 229 ± 90 nmol/l, whereas DU4475 exhibited significantly lesser fluorochrome accumulation (49 ± 22 nmol/l; < 0.01).
Copyright information:
Taken from "Differentiation of angiogenic burden in human cancer xenografts using a perfusion-type optical contrast agent (SIDAG)"
http://breast-cancer-research.com/content/10/2/R23
Breast Cancer Research : BCR 2008;10(2):R23-R23.
Published online 10 Mar 2008
PMCID:PMC2397521.
