Putative Mechanism for ADDL inhibition of RML propagation. from Soluble Aβ aggregates can inhibit prion propagation

Infected PK1/2 cells generate PrPSc by recruitment of PrPC which occurs at a rate faster than the cells innate clearance systems and dilutional effect of cell division, thus the cells remain chronically infected. However when ADDLs are added they bind to PrPC at the cell surface preventing conversion to PrPSc. This reduction in the conversion rate allows the PrPSc to be cleared over time, resulting in reduction in PrPSc levels and cell curing.