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Proton Transfer Hydrogels: Versatility and Applications
journal contribution
posted on 2018-05-16, 12:03 authored by JiHyeon Hwang, Dong G. Lee, Hyunki Yeo, Jingyi Rao, Zhiyuan Zhu, Jawon Shin, Keunsoo Jeong, Sehoon Kim, Hyun Wook Jung, Anzar KhanProton
transfer polymerization between thiol and epoxide groups is shown
to be an adaptable and utilitarian method for the synthesis of hydrogels.
For instance, the polymerization catalyst can be organic or inorganic,
and the polymerization medium can be pure water, buffer solutions,
or organic solvents. The gelation mechanism can be triggered at ambient
conditions, at a physiological temperature of 37 °C, or through
using light as an external stimulus. The ambient and photochemical
methods both allow for nanoimprint lithography to produce freestanding
patterned thick films. The required thiol- and epoxide-carrying precursors
can be chosen from a long list of commercially available small molecular
as well as polymeric materials. The water uptake, mechanical, and
biodegradation properties of the gels can, therefore, be tuned through
the choice of appropriate gelation precursors and polymerization conditions.
Finally, the thio–ether groups of the cross-linked networks
can be functionalized through a postgelation modification reaction
to access sulfonium-based cationic structures. Such structural changes
endow antibacterial properties to the networks. In their pristine
form, however, the gels are biocompatible and nonadhesive, allowing
cancer cells to grow in a cluster formation.
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postgelation modification reactiongelation mechanismbuffer solutionspolymerization conditionscross-linked networkscancer cellsthiolaccess sulfonium-based cationic structuresmethodepoxide-carrying precursorsgelation precursorspolymerization mediumambient conditionsApplications Proton transfer polymerizationepoxide groupsbiodegradation propertiespolymerization catalystnanoimprint lithographywater uptakecluster formationProton Transfer Hydrogels
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