ol802613r_si_001.pdf (4.63 MB)
Probing the Lactose·GM3 Carbohydrate−Carbohydrate Interaction with Glycodendrimers
journal contribution
posted on 2009-02-05, 00:00 authored by Nicole Seah, Paul V. Santacroce, Amit BasuMultivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate−carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.