Principal features of change between cell lines.

(a) Left: real MCF10A nuclear images. Right: heatmap of changes in pixel intensity of MCF10A nuclei after modulation along the first linear discriminant towards HME-1 nuclei. (b) Left: real MCF7 nuclear images. Right: heatmap of changes in pixel intensity of MFC-7 nuclei after modulation along the first linear discriminant towards MDA-MB231 nuclei. (c) Left: real HME-1 nuclear images. Right: heatmap of changes in pixel intensity of HME-1 nuclei after modulation along the first linear discriminant towards MCF10A nuclei. (d) Left: real MDA-MB231 nuclei images. Right: heatmap of changes in pixel intensity of MDA-MB231 nuclei after modulation along the first linear discriminant towards MCF7 nuclei. (e) Logistic regression and feature ablation table on the 4 breast cell lines.

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