Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma-3

S exposed only to vehicle at various doses of bortezomib, POH, or combination of both for 24 hours. Results expressed as mean ± 1SD of triplicate wells. (B) Combination index (CI) plots generated by the computer software CalcuSyn (Biosoft, Cambridge, UK) according to the Chou-Talalay equation ("Materials and Methods") from cytotoxicity data shown in (A). Effect is equivalent to cytotoxicity where effect of 1.0 = 100% relative cytotoxicity. Synergy is present when CI < 1.0. The combination is additive when CI = 1.0, and antagonistic when CI > 1.0.

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Taken from "Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma"

http://www.molecular-cancer.com/content/7/1/40

Molecular Cancer 2008;7():40-40.

Published online 19 May 2008

PMCID:PMC2408930.