PremPDI performance.

Pearson correlation coefficients between experimental and calculated changes in binding free energies (ΔΔG) for “Prempdi” training/test set (a), for two types of cross-validation (CV1 and CV2) (b) and for “leave-one-complex-out” cross-validation (CV3) (c). ROC curves for predictions of deleterious mutations applied on “Prempdi” set (d).