Practical Thiol Surrogates and Protective Groups for Arylthiols for Suzuki−Miyaura Conditions

We have developed practical thiol surrogates and arylthiol protective groups for the Suzuki−Miyaura reaction. 2-Ethylhexyl-3-mercaptopropionate and 4-(2‘-mercaptoethyl)pyridine were shown to be not only good thiol surrogates but also good protective groups for thiol. We have demonstrated toleration of these protective groups under aqueous Suzuki−Miyaura conditions.