jo0507643_si_001.pdf (1.07 MB)
Practical Synthesis of Unsymmetrical Ureas from Isopropenyl Carbamates
journal contribution
posted on 2005-08-19, 00:00 authored by Isabelle Gallou, Magnus Eriksson, Xingzhong Zeng, Chris Senanayake, Vittorio FarinaA very convenient method for the synthesis of unsymmetrical ureas is described, based on isopropenyl carbamates. The synthetic efficiency of traditional methods for urea
formation, such as use of phosgene or alkyl and aryl
carbamates, is limited by the formation of symmetrical urea
side products or reaction reversibility. Isopropenyl carbamates react with amines cleanly and irreversibly and give
unsymmetrical ureas in high yield and purity. This method
is ideal for the rapid synthesis of compound libraries.