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Power analysis for detecting group 1 and group 2 causal SNPs.

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posted on 2017-07-26, 17:56 authored by Lorin Crawford, Ping Zeng, Sayan Mukherjee, Xiang Zhou

We compare the mapping abilities of MAPIT (solid line) to the exhaustive search procedure in PLINK (dotted line) in scenarios I (A), II (B), III (C), and IV (D), under broad-sense heritability level H2 = 0.6 and ρ = 0.8. Here, ρ = 0.8 was used to determine the portion of broad-sense heritability contributed by interaction effects. Group 1 (light red) and group 2 (light blue) causal SNPs. The x-axis shows the false positive rate, while the y-axis gives the rate at which true causal variants were identified. Results are based on 100 replicates in each case.

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