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Plasmonic Nanopowders for Photothermal Therapy of Tumors
journal contribution
posted on 2016-02-20, 19:10 authored by Boris
N. Khlebtsov, Elizaveta V. Panfilova, Georgy S. Terentyuk, Irina L. Maksimova, Andrei V. Ivanov, Nikolai G. KhlebtsovWe describe a novel strategy for the fabrication of plasmonic
nanopowders
(dried gold nanoparticles) by using wet chemical nanoparticle synthesis,
PEG-SH functionalization, and a standard freeze-drying technique.
Our strategy is illustrated by successful fabrication of different
plasmonic nanopowders, including gold nanorods, gold–silver
nanocages, and gold nanospheres. Importantly, the dried nanoparticles
can be stored for a long time under usual conditions and then can
easily be dissolved in water at a desired concentration without such
hard manipulations as sonication or heating. Redispersed samples maintain
the plasmonic properties of parent colloids and do not form aggregates.
These properties make pegylated freeze-dried gold nanoparticles attractive
candidates for plasmonic photothermal therapy in clinical settings.
In this work, redispersed gold nanorods were intravenously administered
to mice bearing Ehrlich carcinoma tumors at doses of 2 and 8 mg (Au)/kg
(animal). Particle biodistribution was measured by atomic absorption
spectroscopy, and tumor hyperthermia effects were studied under laser
NIR irradiation. Significant tumor damage was observed only at the
higher dose of the nanorods.