Phytochemical composition and biological activities of <i>Artemisia quettensis</i> Podlech ethanolic extract

<p>The present study aim to investigate the phytochemical composition, antibacterial, antioxidant and anticancer activities of the ethanolic extract from aerial parts of <i>Artemisia quettensis</i> Podlech. The aerial part of <i>A. quettensis</i> Podlech extract was used for Gas chromatography–mass spectrometry (GC-MS) analysis, antioxidant, antibacterial and <i>anticancer activities</i>. GC/MS analysis of extract from this plant showed 23 major components and the most dominant components were acetic acid, [4-(1-hydroxy-1-methylethyl) cyclohex-1-enyl] methyl ester (13.88%), trans-Phytol (10.06%) and 2,6-Dimethyl-2,6-octadiene-1,8-diol diacetate (6.8%). The extract had significant antibacterial and anticancer effects. The highest percentage of antioxidant activity was 78.46% at 2 mg/mL concentration of extract. Moreover, the highest antibacterial effects of extract were against to gram-positive bacteria and the IC<sub>50</sub> cell cytotoxicity value on HT29 cell line in 24 h, 48 h and 72 h were 31.54, 6.08 and 2.96 mg/mL, respectively. From this study, <i>A. quettensis</i> Podlech could be considered as a promising source for novel drug compounds.</p>