ja211888a_si_001.pdf (1.41 MB)
Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
journal contribution
posted on 2015-12-16, 21:26 authored by Rong Tong, Houman D. Hemmati, Robert Langer, Daniel S. KohaneWe report a novel nanoparticulate drug delivery system
that undergoes
reversible volume change from 150 to 40 nm upon phototriggering with
UV light. The volume change of these monodisperse nanoparticles comprising
spiropyran, which undergoes reversible photoisomerization, and PEGylated
lipid enables repetitive dosing from a single administration and enhances
tissue penetration. The photoswitching allows particles to fluoresce
and release drugs inside cells when illuminated with UV light. The
mechanism of the light-induced size switching and triggered-release
is studied. These particles provide spatiotemporal control of drug
release and enhanced tissue penetration, useful properties in many
disease states including cancer.