jp304708y_si_001.pdf (1.02 MB)
Photophysical Probes To Assess the Potential of Cholic Acid Aggregates as Drug Carriers
journal contribution
posted on 2012-08-30, 00:00 authored by Miguel Gomez-Mendoza, Edurne Nuin, Inmaculada Andreu, M. Luisa Marin, Miguel A. MirandaThe two enantiomers of the nonsteroidal antiinflammatory
drug naproxen
and of its methyl ester have been selected as representative probes
with markedly different hydrophobicity to assess the potential of
cholic acid aggregates as drug carriers by means of photophysical
techniques. The different distribution of the probes between bulk
solution and aggregates has been assessed by quenching of their singlet
and triplet excited states by iodide and nitrite anions, respectively.
This straightforward photophysical methodology can, in principle,
be extended to a variety of drugs containing a photoactive chromophore.