Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis of <i>trans</i>-2,3-Dihydrobenzofurans from Salicyl <i>N</i>-Thiophosphinyl Imines and Allylic Carbonates

2010-09-03T00:00:00Z (GMT) by Peizhong Xie You Huang Ruyu Chen
A novel phosphine-catalyzed domino reaction of salicyl <i>N</i>-thiophosphinyl imines and allylic carbonates was developed. The allylic carbonate, in this reaction, serves as a new kind of 1,1-dipolar synthon. This method offered a powerful approach to the construction of a highly substituted <i>trans</i>-2,3-dihydrobenzofuran skeleton with high diastereoselectivity.