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Phenylboronic Acid Templated Gold Nanoclusters for Mucin Detection Using a Smartphone-Based Device and Targeted Cancer Cell Theranostics
journal contribution
posted on 2017-12-04, 00:00 authored by Deepanjalee Dutta, Sunil Kumar Sailapu, Arun Chattopadhyay, Siddhartha Sankar GhoshA phenylboronic
acid templated gold nanocluster probe was developed to detect biomarker
mucin by a noninvasive fluorescence-based method using a point-of-care
smartphone-based fluorescence detection device. The gold nanocluster
probe is able to detect mucin specifically. The same probe was applied
for in vitro targeted bioimaging of HeLa and Hep G2 cancer cells,
and it demonstrated specific therapeutic effects toward cancer cells
as well as multicellular tumor spheroids imparting theranostic properties.
The module is found to be more effective toward HeLa cells, and a
pathway of cell death was established using flow-cytometry-based assays.
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noninvasive fluorescence-based methodcancer cellsSmartphone-Based Devicebiomarker mucinTemplated Gold NanoclustersTargeted Cancer Cell Theranosticsgold nanocluster probecell deaththeranostic propertiesflow-cytometry-based assaysHep G 2 cancer cellsmulticellular tumor spheroidspoint-of-care smartphone-based fluorescence detection deviceMucin DetectionHeLa cellsphenylboronic acid templated gold nanocluster probe
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