Phenotype of DKO mice.

<p>(A) Representative photograph of <i>t2</i> KO pups and cyanotic DKO littermates at E18.5. Scale bar: 1 cm. (B) Body weight of <i>t2</i> KO (n = 68) and DKO (n = 51) embryos at E18.5. *<i>P</i> < 0.05. (C) Lung sections from <i>t2</i> KO embryos and DKO littermates were stained with HE. Scale bar: 100 μm. (D-H) Skeletal whole body (D), upper limb (E), lower limb (F), lumber spine (G), and cranial bone (H) preparation. (I) Humeral and tibial bone length at E18.5 of <i>t2</i> KO (n = 5) and DKO (n = 10) mice. **<i>P</i> < 0.01.</p>