Pharmacological interactions between pemetrexed, cisplatin and cSBL in H2452 and MSTO cells.

<p>(A) CI values of each combination (CI = 1 indicates an additive effect; CI<1 indicates a synergistic effect; and CI>1 indicates an antagonistic effect). (B) DRI values of each reagent (DRI = 1 indicates no dose reduction; whereas DRI >1 and <1 indicate favorable and unfavorable dose-reductions, respectively). Pem or P, pemetrexed; Cis or C, cisplatin; S, cSBL.</p>