Pharmacological inhibition of Nox2 oxidase activity.

Effect of apocynin (Apo, 2.5 mg/kg) treatment on (A) BALF cellularity, (B) BALF inflammatory cell superoxide production and (C) viral titer in H3N2 (X-31) influenza A virus-infected WT mice 3 days post infection. Also, effect of apocynin treatment on (D) BALF cellularity and (E) BALF inflammatory cell superoxide production in H1N1 (PR8) influenza A virus-infected WT mice 3 days post infection. Data are shown as mean ± SD for 6–8 mice per treatment group. *P<0.05 vs WT vehicle (Control)-treated mice (ANOVA followed by Dunnett's post hoc test for (A and D) but Students' unpaired t test used for B, C and E).