Fig 4.tif (1.9 MB)
Perivascular localization of the podoplanin-expressing cells.
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posted on 2017-03-23, 18:02 authored by Maria Cimini, Antonio Cannatá, Gianandrea Pasquinelli, Marcello Rota, Polina GoichbergThin cardiac sections were indirectly immunolabeled with podoplanin (red) and VEGFR-2 (green) antibodies. Nuclei, blue. Time after MI is indicated. Areas in rectangles are shown at a higher magnification in the adjacent images for each color channel and merged. Note the podoplanin-positive cells encircling the VEGFR-2-labeled BVs.
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lymphatic networkscar developmentartery ligationlymphatic vessel growthsham-operated counterpartslymphatic endotheliumPodoplanin-carrying populationsPodoplanin immunoreactivityinfarcted adult heartinfarcted myocardiumpodoplanin-containing cellsinfarcted heartmesenchymal markersinfarcted heartsinfarcted regionscar formationVEGFR -3podoplanin-expressing cell populationspodoplanin-labeled cellsspatiotemporal changesextracellular matrix depositsLYVE -1-negative cellsfibrogenic responsesVEGFR -2 contentblood vesselspodoplanin-positive cell compartmentpost-MI lymphangiogenesismouse modelwound granulationinfarcted myocardium Cardiac lymphatic vasculatureLYVE -1-positive lymphatic vesselspro-fibrotic cellsmaster regulatorPDGFRfibrotic areahematoendothelial epitope CD 34.podoplanin-presenting cellspodoplanin-rich LYVE -1-negative multicellular assembliesProx -1-positive
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