lsyc_a_1455872_sm1994.doc (3.03 MB)
Pd-catalyzed regioselective C-H chlorination of disubstituted 1,2,3-triazoles
journal contribution
posted on 2018-05-23, 12:46 authored by Xinyuan Ma, Qiong Mo, Jie Chang, Kai XieThis paper mainly studied Pd-catalyzed regioselective chlorination of disubstituted 1,2,3-triazoles directed by the 1,2,3-triazole ring. A series of regioselective chlorinated products were synthesized in 47–86% yields using Pd(OAc)2 as a catalyst and CuCl2 as a chlorinated reagent. This method provides a new mean for the synthesis of 1,2,3-triazole halides which combines the formation of C-X bond with C-H activation.