Pattern of Notum expression.

(A) Total RNA was extracted from various mouse tissues and Notum mRNA assayed by quantitative RT-PCR. Results are normalized to those for 18S transcripts and the means ± S.D. of triplicate samples are presented. (B) Representative picture of Notum in situ hybridization with WT, NotumKOLiv or APCΔex14/Δex14 mice liver. Portal spaces (PS) and hepatic centrilobular vein (CV) are indicated.