Palladium-Catalyzed Intramolecular Aminotrifluoromethoxylation of Alkenes

The first catalytic trifluoromethoxylation of unactivated alkenes has been developed, in which Pd­(CH₃CN)₂Cl₂ was used as catalyst, AgOCF₃ as trifluoromethoxide source, and Selectfluor-BF₄ as oxidant. A variety of 3-OCF₃ substituted piperidines were selectively obtained in good yields. Direct evidence was provided to address the facile reductive elimination of Pd^IV–OCF₃ complex to form sp³ C–OCF₃ bond.