ol7b03808_si_001.pdf (4.18 MB)
Palladium-Catalyzed Four-Component Cascade Reaction for the Synthesis of Highly Functionalized Acyclic O,O‑Acetals
journal contribution
posted on 2018-01-16, 22:43 authored by Wenfang Xiong, Donghao Yan, Chaorong Qi, Huanfeng JiangA palladium-catalyzed four-component
cascade reaction of carbon
dioxide, amines, allenyl ethers, and aryl iodides has been developed
for the first time. The novel reaction allows simultaneous construction
of three different new bonds (C–N, C–O, and C–C)
in a single step, affording an efficient method for the synthesis
of a variety of highly functionalized acyclic O,O-acetals. Excellent chemo- and regioselectivity, wide substrate
scope, and good functional group tolerance are features of the method.
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carbon dioxidearyl iodidesAcetalExcellent chemosynthesissubstrate scopevarietygroup toleranceFunctionalized Acyclic Onovel reactionacetalmethodSynthesiaminesregioselectivityconstructionpalladium-catalyzed four-component cascade reactionallenyl ethersPalladium-Catalyzed Four-Component Cascade Reactionfunctionalized acyclic Obond
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