ol8b00949_si_001.pdf (5.48 MB)
Palladium-Catalyzed Decarbonylative Alkynylation of Amides
journal contribution
posted on 2018-04-20, 16:49 authored by Long Liu, Dan Zhou, Min Liu, Yongbo Zhou, Tieqiao ChenA palladium-catalyzed
decarbonylative alkynylation of amides via
C–N bond activation is developed. Compared with the reported
Ni/Cu catalyzed reaction, which only proceeded well with silylacetylenes,
this transformation was also applicable to both aromatic and aliphatic
terminal alkynes, including those bearing functional groups, and thus
provided a general and straightforward access to diverse internal
alkynes.