ol7b02927_si_001.pdf (21.89 MB)
Palladium-Catalyzed Asymmetric Allylic Alkylation of Alkyl-Substituted Allyl Reagents with Acyclic Amides
journal contribution
posted on 2017-10-18, 14:19 authored by Yang-Jie Jiang, Gao-Peng Zhang, Jian-Qiang Huang, Di Chen, Chang-Hua Ding, Xue-Long HouA wide range of alkyl-substituted
allyl reagents, as well as nonstabilized
carbon nucleophiles, was successfully used for the first time in the
palladium-catalyzed asymmetric allylic alkylation reaction, affording
the corresponding allylic alkylated products in high yields with high
enantioselectivities. The usefulness of the protocol has been demonstrated
by the enantioselective synthesis of an important chiral building
block and enantiomer of Dubiusamine A.
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chiral building blockusefulnessDubiusamineAcyclic Amidesallylic alkylated productsAlkyl-Substituted Allyl Reagentsenantiomerenantioselective synthesisenantioselectivitieallylic alkylation reactionpalladium-catalyzedPalladium-Catalyzed Asymmetric Allylic Alkylationnonstabilized carbon nucleophilesalkyl-substituted allyl reagentsyield
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