Oxidatively rearranged cycloartane triterpenoids from the seeds of Pseudolarix amabilis

Guo, Hui; Yao, Shen; Yang, Xinyi; Chen, Yunfei; Chen, Yan; Gong, Feng; Tong, Jun; Qian, Junqing; Zhang, Ailian; Cai, Xiaohua

doi:10.6084/m9.figshare.5631931.v1

gnpl_a_1405406_sm7170.pdf (1.01 MB)

Oxidatively rearranged cycloartane triterpenoids from the seeds of Pseudolarix amabilis

journal contribution

posted on 2017-11-24, 12:23 authored by Hui Guo, Shen Yao, Xinyi Yang, Yunfei Chen, Yan Chen, Feng Gong, Jun Tong, Junqing Qian, Ailian Zhang, Xiaohua Cai

One novel and eight known oxidatively rearranged cycloartane triterpenoids were isolated from the seeds of Pseudolarix amabilis. The structure of the new isolate was elucidated on extensive spectroscopic analyses. Results indicated that pseudolarolide Q (4) exhibited strong antimicrobial activity against Gram-positive Staphylococcus aureus and Candida albicans at the MICs of 6.08 and 24.32 μM, respectively. Pseudolarolide I (2) showed the 11β-HSD1 inhibitory property at the IC₅₀ value of 34.5 nM.