Oxidative Coupling of <i>o</i>-Phenylenediamine with Arylmethylamines to Synthesize Aryl-Substituted Benzimidazoles Under Catalyst-Free and Solvent-Free Conditions

2014-07-09T01:13:11Z (GMT) by Jiatao Yu Ming Lu
<div><p></p><p>Solvent-free oxidative synthesis of benzimidazoles from arylmethylamines and <i>o</i>-phenylenediamine has been achieved under catalyst-free conditions. This reaction can use tert-butyl hydroperoxide (TBHP) as the oxidant, and a wide variety of derivatives were obtained in good yields. The reaction mechanism was proposed and this method provides a direct and practical approach for the preparation of substituted benzimidazoles.</p> </div>