Fig 3.tif (193.61 kB)
Overall survival and cumulative incidence of relapse.
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posted on 2017-09-27, 17:41 authored by Yang Jo Chung, Terry J. Fry, Peter D. Aplan(A) Log RANK test for Non-HSCT vs S-HSCT, p = 0.0013; Non-HSCT vs A- HSCT, p = 0.0054; Allo HSCT vs Syn HSCT, p = 0.7373. Non-HSCT NHD13 refers to NHD13 transgenic mice not subjected to myeloablative irradiation and HSCT. WT-HSCT refers to WT recipient mice transplanted with WT syngeneic BMNC following myeloablative irradiation. (B) Cumulative incidence of relapse for S-HSCT and A-HSCT.
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GVL effectnon-transplanted NHD 13 controlssyngeneic bone marrowrelapse ratedonor bone marrowA-HSCTmyelodysplastic syndrome Allogeneic hematopoieticNHD 13 miceHSCTS-HSCTdisease remissionNUPNHD 13 recipientscell transplantationallogeneic bone marrowdonor splenocytesGVHD54 weeks post-transplant98-HOXDradio-resistant MDS clonemodel
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