A novel series of bis (phenylimino dihydro thiazolyl-2H-chromene) derivatives have been synthesized through an efficient one-pot multicomponent approach involving different substituted of 3-(2-bromoacetyl)-2H-chromen-2-ones, phenyl isothiocyanates and para-phenylenediamine in presence of dimethylformamide solvent. The target compounds were obtained in a shorter reaction time through simple reaction work up with good yields. All the synthesized products were characterized by their spectral and analytical data like IR, 1H NMR, 13C NMR, Roesy, and mass spectral data.