jo052640w_si_003.cif (21.45 kB)
One-Step Assembly of Carbamoyl-Substituted Heteroannelated [1,4]Thiazepines
dataset
posted on 2006-03-31, 00:00 authored by Alexey P. Ilyn, Marina V. Loseva, Vladimir Y. Vvedensky, Elena B. Putsykina, Sergey E. Tkachenko, Dmitri V. Kravchenko, Alexandr V. Khvat, Mikhail Y. Krasavin, Alexandre V. IvachtchenkoWe present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and
5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We
demonstrate the usefulness and versatility of the developed approach for the synthesis of variously
substituted compounds and discuss the scope and limitations of the chemistry involved.
