One-Pot Synthesis of 2-Substituted Indoles from 2-Aminobenzyl Phosphonium Salts. A Formal Total Synthesis of Arcyriacyanin A

2008-07-17T00:00:00Z (GMT) by George A. Kraus Haitao Guo
The reaction of (2-aminobenzyl) triphenylphosphonium bromide with aromatic aldehydes or α,β-unsaturated aldehydes under <i>microwave-assisted conditions</i> constitutes a new synthesis of 2-substituted indoles in high yields (81−97%) in a one-pot reaction. The adduct from indole-4-carboxaldehyde was an advanced intermediate in the synthesis of arcyriacyanin A.