One-Pot, Catalytic, Asymmetric Synthesis of Polypropionates

The opening of methylketene dimer, followed by aldol reactions of the resulting enolate, provides a convenient access to <i>syn</i>,<i>syn</i>-dipropionate aldol adducts of a variety of aldehydes. These aldol adducts are useful precursors in the synthesis of complex polypropionates.