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OSU53 activates AMPK in human osteoblastic cells.
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posted on 2016-09-15, 17:49 authored by Dawei Xu, Wei Zhao, Xinhui Zhu, Jianbo Fan, Shengyu Cui, Yuyu Sun, Xiang Chen, Wei Liu, Zhi-ming CuiHuman osteoblastic OB-6 cells were treated with or without OSU53 (10 μM) for two hours, expression of listed proteins was tested by Western blots (A). p-ACC level (vs. regular ACC) was quantified (B). “Ctrl” stands for untreated control group (Same for all figures). Experiments in this figure were repeated three times, and similar results were obtained. *p<0.05 vs. “Ctrl” group (B).
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Dex-induced osteoblastic OB -6 cell deathOSU 53-induced AMPK activationDex-treated osteoblastic cellsOSU 53novel AMPK activatoralleviated Dex-induced oxidative stress172AActivating AMPK Signaling Excessive dexamethasoneOB -6 cellsOSU 53-induced actionsOSU 53 Rescues Human OB -6 Osteoblastic CellsNADPHOB -6 osteoblastic cellsapplication causes osteoblast cell deathnicotinamide adenine dinucleotide phosphateOB -6 cell protectionOSU 53. OSU 53AMP-activated protein kinase
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