## Numerical simulations of the model of homologous PB regimes with different parameters values.

2018-01-12T09:09:35Z (GMT) by
<p>A). Behavior of effector T cells after prime according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.e001" target="_blank">Eq (1)</a>. PB protocols are defined by choosing nine boost timings equally distributed between the initiation of the T cell response and the end of clonal contraction. B) Memory T cells formed for PB protocols that differ in prime dose and boost time, using a high total antigen dose. C) As B with lower antigen load. Results are normalized relative to the maximum in each figure. Black planes show the minimum value of memory formation for comparison. D,E) Same as B and C for a different choice of parameter values. The values of the parameters used in these simulations are the following (in suitable units): (B) <i>A</i><sub>0</sub> = 20000, <i>λ</i><sub><i>A</i></sub> = 450, <i>c</i> = 40, <i>k</i> = 250, <i>λ</i><sub><i>H</i></sub> = 10, <i>φ</i> = 10<sup>7</sup>, <i>μ</i> = 1, <i>α</i> = 15, <i>β</i> = 0.04 and <i>E</i><sub><i>a</i></sub>(0) = <i>M</i><sub><i>a</i></sub>(0) = 10. (C) Same as in B, with <i>A</i><sub>0</sub> = 200. (D) <i>A</i><sub>0</sub> = 10000, <i>λ</i><sub><i>P</i></sub> = 250, <i>c</i> = 50, <i>k</i> = 120, <i>λ</i><sub><i>H</i></sub> = 10, <i>φ</i> = 10<sup>7</sup>, <i>μ</i> = 1, <i>A</i><sub>0</sub> = 10<sup>7</sup>, <i>μ</i> = 1, <i>α</i> = 2, <i>β</i> = 0.2 and <i>E</i><sub><i>a</i></sub>(0) = <i>M</i><sub><i>a</i></sub>(0) = 10. (E) Same as in C, with <i>A</i><sub>0</sub> = 1000.</p>