jo0355045_si_011.pdf (75.04 kB)
Novel Betaines from a Micronesian Sponge Dysidea herbacea
journal contribution
posted on 2004-02-20, 00:00 authored by Ryuichi Sakai, Katsuji Suzuki, Keiko Shimamoto, Hisao KamiyaThree new betaines, dysibetaine PP (1), dysibetaine CPa (2), and dysibetaine CPb (3), were isolated
from an aqueous extract of the marine sponge Dysidea herbacea collected in Yap state, Micronesia.
The structure of 1 was determined by spectral methods as well as chemical degradation to be a
novel dipeptide betaine, and those for 2 and 3 were determined to be unprecedented cyclopropane
betaines. Compounds 2 and 3 showed weak affinity toward the N-methyl-d-aspartic acid-type and
the kainic acid-type glutamate receptors, respectively, in a radioligand binding assay.