Novel BODIPY-Based Fluorescence Turn-on Sensor for Fe<sup>3+</sup> and Its Bioimaging Application in Living Cells

A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe<sup>3+</sup> in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe<sup>3+</sup>-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe<sup>3+</sup> detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe<sup>3+</sup> in living cells.