Novel Approach to 3,4-Dihydro-2(1H)-quinolinone Derivatives via Cyclopropane Ring Expansion

Tsuritani, Takayuki; Yamamoto, Yuhei; Kawasaki, Masashi; Mase, Toshiaki

doi:10.1021/ol802669r.s001

ol802669r_si_001.pdf (3.16 MB)

Novel Approach to 3,4-Dihydro-2(¹H)-quinolinone Derivatives via Cyclopropane Ring Expansion

journal contribution

posted on 2009-03-05, 00:00 authored by Takayuki Tsuritani, Yuhei Yamamoto, Masashi Kawasaki, Toshiaki Mase

N-(1′-Alkoxy)cyclopropyl-2-haloanilines are transformed to 3,4-dihydro-2(¹H)-quinolinones via palladium-catalyzed cyclopropane ring expansion. The reaction tolerates a variety of functional groups such as ester, nitrile, ether, and ketone groups.

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Keywords

nitrile Derivative ether variety Cyclopropane ester ketone groups cyclopropane Novel Approach Dihydro ExpansionN dihydro

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