Non-alkaloids extract from <i>Stemona sessilifolia</i> enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells

<p>One of the major impediments to the successful treatment of cancer is the development of resistant cancer cells, which could cause multidrug resistance (MDR), and overexpression of ABCB1/P-glycoprotein (P-gp) is one of the most common causes of MDR in cancer cells. Recently, natural products or plant-derived chemicals have been investigated more and more widely as potential multidrug-resistant (MDR) reversing agents. The current study demonstrated for the first time that non-alkaloids extract from <i>Stemona sessilifolia</i> significantly reversed the resistance of chemotherapeutic agents, adriamycin, paclitaxel and vincristine to MCF-7/ADR cells compared with MCF-7/S cells in a dose-dependent manner. The results obtained from these studies indicated that the non-alkaloids extract from <i>S. sessilifolia</i> plays an important role in reversing MDR of cancer as a P-gp modulator <i>in vitro</i> and may be effective in the treatment of multidrug-resistant cancers.</p>