np5b00894_si_001.pdf (7.58 MB)
Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from Artemisia rupestris
journal contribution
posted on 2016-01-22, 00:00 authored by Chen Zhang, Shu Wang, Ke-Wu Zeng, Jun Li, Daneel Ferreira, Jordan
K. Zjawiony, Bing-Yu Liu, Xiao-Yu Guo, Hong-Wei Jin, Yong Jiang, Peng-Fei TuTwelve new dimeric sesquiterpenoids
(1–12) were isolated from the dried
whole plants of Artemisia
rupestris. Their structures were determined using MS and
NMR data, and the absolute configurations were elucidated on the basis
of experimental and calculated ECD spectra. Compounds 1–9 are presumably formed via biocatalyzed [2+2]
or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder
reaction dictated the formation of endo-products.
The dimeric sesquiterpenoids exhibited moderate inhibition on NO production
stimulated by lipopolysaccharide in BV-2 microglial cells, with IC50 values in the range 17.0–71.8 μM.