Nickel-Catalyzed Direct C (sp3)–H Arylation of Aliphatic Amides with Thiophenes

Nickel-catalyzed heteroarylation of the inactive methyl C­(sp3)–H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes.