Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes Initiated by Radical Alkylation with Tertiary α‑Carbonyl Alkyl Bromides

A novel nickel-catalyzed remote arylation of alkenyl aldehydes triggered by radical alkylation with tertiary α-carbonyl alkyl bromides is described, thus producing a quaternary carbon center containing ketones in promising yields with broad functional group compatibility. Preliminary mechanistic studies suggest that the combination of a 1,<i>n</i>-HAT (<i>n</i> = 5 or 6) from alkyl radicals to aldehyde C–H bonds with nickel catalysis may account for the realization of this reaction.