ol8b00070_si_001.pdf (5.25 MB)
Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow
journal contribution
posted on 2018-02-12, 05:40 authored by Hui Li, Christopher P. Breen, Hyowon Seo, Timothy F. Jamison, Yuan-Qing Fang, Matthew M. BioAn electrochemically
driven, nickel-catalyzed reductive coupling
of N-hydroxyphthalimide esters with aryl halides
is reported. The reaction proceeds under mild conditions in a divided
electrochemical cell and employs a tertiary amine as the reductant.
This decarboxylative C(sp3)–C(sp2) bond-forming
transformation exhibits excellent substrate generality and functional
group compatibility. An operationally simple continuous-flow version
of this transformation using a commercial electrochemical flow reactor
represents a robust and scalable synthesis of value added coupling
process.
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electrochemical cellamineDecarboxylativecontinuous-flow versiongroup compatibilityreductantaryl halidesnickel-catalyzed reductivescalable synthesisdecarboxylativeelectrochemicallyreaction proceedsCouplinghydroxyphthalimide estersBatchbond-forming transformation exhibitselectrochemical flow reactorsubstrate generalityElectrochemicalContinuous FlowNi-Catalyzed
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