New angular oxazole-fused coumarin derivatives: synthesis and biological activities

2017-11-21T02:53:15Z (GMT) by Yan Wei Shi-qiang Li Shuang-hong Hao
<p>Twelve angular oxazole-fused coumarin derivatives were designed, synthesised and characterised by <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. The structure of compound <b>4a</b> was further confirmed by X-ray single-crystal diffraction. The bioassay experiment results indicated that compounds <b>4f</b> and <b>4l</b> have high antifungal activity on the mycelium growth of 4 plant disease fungi. Especially, compound <b>4l</b> has a stronger antifungal activity compare to the commercial fungicide, Carbendazim. The herbicidal activity experiment showed that <b>4a</b> and <b>4b</b> can significantly inhibit the taproot and caulis development of <i>Chenopodium album</i> seedling and have better activities than the commercial herbicide, Acetochlor.</p>